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09.11.16
 
Discoveries in Autophagy: While the cytoplasmic components of autophagy have been progressively unveiled, transcriptional and epigenetic regulation of autophagy is poorly understood. The new findings demonstrate that the histone arginine methyltransferase CARM1 acts a critical co-activator of TFEB to initiate autophagy-related gene expression and that autophagy induction can be regulated by the AMPK - SKP2 - CARM1 signaling axis, in response to cellular starvation. (Nature, 2016)
             
     
PAB30239   PAB30240   PAB30236   PAB30237
ATG 4C polycl. Ab   ATG 7 polycl. Ab   GNPTG polycl. Ab   PSPAP polycl. Ab
IF staining of human glioblastoma astrocytoma cells with ATG4C polycl. antibody shows positivity (Green) in cytoplasm and nucleus but not in the nucleoli.   IF staining of human epidermoid carcinoma cells (A-431) with ATG7 polyclonal antibody shows positivity (Green) in cytoplasm.   IF staining of human osteosar- coma cells (U-2 OS) with GNPTG polyclonal antibody shows positivity (Green) in endoplasmic reticulum.   IF staining of human osteosar- coma cells (U-2 OS) with PSAP polyclonal antibody shows positivity (Green) in vesicles.
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