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Featured: Th17 Antibody pairs

For researchers looking to build their own sandwich ELISAs, BioLegend offers convenient antibody pairs and recombinant standards.

IL-23, a key cytokine for Th17 development and expansion. Th17 cells are heavily involved in EAE, a mouse model of multiple sclerosis. Chung and Liao investigated the effects of knocking out CXCR3 in Th17 infiltration and glial cell cytokine production in the central nervous system (CNS) and showed increased Th17 cells in the CNS, leading to more severe EAE. When present and engaged, CXCR3 also promotes IFNγ and IL-12 production, which would antagonize Th17 development. In addition, CXCR3 signaling in glial cells was shown to suppress NF-κB, which could limit overproduction of pro-Th17 cytokines.

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