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Defective signalling by protein kinases accounts for more than 400 human diseases. Mutations in kinases can also confer drug resistance, which poses an increasing challenge to development of effective therapeutics. Targeting protein kinases by small molecule inhibitors or neutralizing antibodies has been extremely beneficial in the treatment of various human diseases. More than 10 drugs targeting protein kinases have been approved while another 60 candidates are in clinical trials.

SignalChem offers the most extensive range of Kinases, medically relevant human recombinant Active Kinase Mutants, Kinase Proteins and Antibodies against Kinases, specially to support functional studies and development for the next generation of kinase drugs.

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Kinase Activators / Inhibitors
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