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18.03.2015
 
Tau-Proteins    
SignalChem offers a comprehensive range of Tau-Proteins, Anti-phospho-Tau Antibodies & Tau-siRNA
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The Tau family of proteins function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (β-APP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).
 
1. Zilka, N., et al. FEBS Lett. 2006      2. Rial, A. et al. J. Biol. Chem., 2004  
 
New at SignalChem
BRAF, Active KIAA1549-BRAF Mutant (Kex15Bex9), Active BRAF Mutant (V600D), Active
BRAF Mutant (G464V), Active KIAA1549-BRAF Mutant (Kex16Bex9), Active BRAF Mutant (V600K), Active
BRAF Mutant (G469A), Active RNF130-BRAF Mutant (Rex3Bex9), Active BRAF Mutant (d485-489 P490Y), Active
BRAF Mutant (L597V), Active BRAF Mutant (R506_K607insVLR), Active  
 
Kinases
All Active Kinases
All Active Kinase Mutants
Unactive Kinases
Protein Kinases
Fructose Kinases
Lipid Kinases
Ser/Thr Kinases
Receptor Tyrosine Kinases
Cytoplasmic Tyrosine Kinases
 
Biochemical Compounds
Kinase Activators
Kinase Inhibitors
 
Signaling Reagents
Assay Reagents
Oligo Substrates
Peptide Substrates
Protein Substrates
 

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