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SignalChem offers a comprehensive range of Tau-Proteins, Anti-phospho-Tau Antibodies & Tau-siRNA
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The Tau family of proteins function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (β-APP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).
1. Zilka, N., et al. FEBS Lett. 2006      2. Rial, A. et al. J. Biol. Chem., 2004  
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BRAF, Active KIAA1549-BRAF Mutant (Kex15Bex9), Active BRAF Mutant (V600D), Active
BRAF Mutant (G464V), Active KIAA1549-BRAF Mutant (Kex16Bex9), Active BRAF Mutant (V600K), Active
BRAF Mutant (G469A), Active RNF130-BRAF Mutant (Rex3Bex9), Active BRAF Mutant (d485-489 P490Y), Active
BRAF Mutant (L597V), Active BRAF Mutant (R506_K607insVLR), Active  
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