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  AXIN1 and AXIN2   NEW!            

The Wnt/beta-catenin pathway is highly regulated to ensure the correct temporal and spatial activation of its target genes. When beta-catenin levels become elevated in the cytosol, excess beta-catenin translocates into the nucleus. Nucleo-cytoplasmic shuttling of beta-catenin is negatively regulated by the destruction complex, composed of AXIN, adenomatosis polyposis coli (APC), protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1alpha (CK1alpha). AXIN acts as a scaffold between GSK3 and beta-catenin to enable the former to effectively phosphorylate the latter.

Mutations and dysregulated expression of Wnt signaling proteins such as AXIN1 and beta-catenin are frequently observed in many cancers.

SignalChem offers purified recombinant AXIN1 and AXIN2 along with other purified recombinant components of the Wnt/beta-catenin pathway to facilitate the study of this disease-relevant pathway.

Sucrose non-fermenting 1-related kinase (SNRK) is a serine/threonine kinase that is related to AMP-activated protein kinases (AMPKs). Like other AMPK-family members, SNRK is substrate of the tumor suppressor, LKB1. SNRK is activated by environmental and metabolic signals such as osmotic stress and energy depletion. SNRK responds to these signals by limiting energy-consumption and by promoting catabolic processes that conserve and produce energy such as carbohydrate metabolism and lipid biosynthesis. Depletion of SNRK leads to overweight in mice, suggesting that SNRK may have far reaching effects on obesity. Mutations in SNRK are associated with vascular anomalies, which are caused by defects in migration, maintenance, and differentiation of angioblasts. In cancer, overexpression of SNRK leads to reduced cell proliferation by directly preventing beta-catenin signaling in two ways: SNRK targets beta-catenin for ubiquitin mediated degradation and it also disrupts beta-catenin's ability to localize to the nucleus.

SignalChem offers SNRK active kinase and related signaling proteins and reagents.
  NEW at SignalChem
Product Catalog #   Product Catalog #
AXIN1 Protein A71-30G EPHB6 Protein E26-35G
AXIN2 Protein A72-30G H11 (HSP22) Protein H09-34G
EGFR Mutant (D761Y), Active E10-12QG RIOK1 Protein R04-34G
EGFR Mutant (D770GY), Active E10-13KG RIOK2 Protein R05-34G
EGFR Mutant (G719D), Active E10-12GG RIOK3 Protein R06-34G
EGFR Mutant (L747S), Active E10-12PG SNRK, Active S16-10G
EGFR Mutant (P772_H773insNPH), Active E10-13MG SBK1, Active S56-10G
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