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The serine/threonine-protein kinase Receptor Interacting Protein Kinase 1 (RIPK1) is required for tumor necrosis factor receptor 1 (TNFR1)-driven necrotic cell-death (necroptosis). When TNFR1 is stimulated by TNF or Fas, it interacts with adaptor proteins (FADD and TRADD), which bridge the interaction between TNFR1 and RIPK1. Activated RIPK1 then associates with RIPK3 to form a necroptosis-inducing complex. RIPKs are also responsive to pathogen recognition receptors (PRRs), inflammation and DNA damage. Necroptosis serves as an alternative to apoptosis and is implicated in the pathogenesis of a variety of human diseases such as brain injury, immune disorders and cancer.

SignalChem offers active RIPK1 and related reagents to support TNFR-signaling research.

  New in May 2014
Product Catalog #   Product Catalog #
ALK2 Mutant (Q207D), Active A06-13CG HtrA (S234A) Protein H531-36CH
ALK2 Mutant (Q207E), Active A06-13DG HtrA Protein H531-30CH
ASK3 Protein M73-31G HTRA1 Protein H531-30H
EGFR Mutant (d747-752 P753S), Active E10-12NG HTRA4 Protein H534-31H
EGFR Mutant (G719C), Active E10-12FG KSR1, Active K07-11BG
EGFR Mutant (G719S), Active E10-12HG MAK, Active M01-10G
HER2 Mutant (d755-759), Active E27-12BG RIPK1, Active R07-10G
HER2 Mutant (G776VC), Active E27-13EG Tau-383 (N352H) Protein T05-56N
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