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03.07.2013  
Cyclin-Dependent Kinases

Cyclin-dependent kinases (CDKs) are evolutionarily conserved protein kinases that have well established roles in cell cycle regulation and other key processes including gene regulation. CDKs contain catalytic kinase activity and are regulated by the binding of cyclin subunits. CDKs are positively regulated by cyclins, and as their names suggest the concentrations of cyclins rise and fall during the cell cycle. Conversely, CDKs are inhibited when bound to CIP and INK4 subunits. Dysregulated CDKs are observed in a wide range of cancers and this is not surprising due to their roles in controlling cell cycle progression and proliferation.

SignalChem offers a growing selection of high-quality individual CDKs and CDK complexes to facilitate the study of these targets and their downstream pathways. Browse...

 
Tau Mutants
Tau proteins are represented by several isoforms, which are produced from a single gene via alternative splicing. They are enriched in the neurons of the central nervous system where they interact with tubulin to promote microtubule stability and assembly. Normally, Tau proteins are soluble; however, hyperphosphorylation or mutations in their microtubule binding repeat region leads to neurofibrillary tangles and intra-neuronal deposits. These filamentous deposits are causal factors for a number of neurodegenerative diseases such as frontotemporal dementia, Alzheimer's Disease, and Parkinson's Disease. Browse...
 
Methyltransferase Proteins

Methyltransferases (a.k.a. methylases) are enzymes that catalyze the addition of methyl groups onto acceptor molecules such as histones and DNA. Histone methyltransferases target histone tails to activate or repress transcription. DNA methyltransferases transfer methyl groups from S-Adenosyl methionine (SAM) to cytosine residues. DNA methylation can protect DNA from enzymatic cleavage and hypomethylation and hypermethylation are linked with cancer. Therefore, DNA and histone methylation profiling is a useful tool for investigating the underlying causes for cancer.

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