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06.04.2011  
 
Like T helper cells, macrophages also polarize to distinct phenotypes expressing unique cell surface molecules and secreting discrete sets of cytokines and chemokines. The classical M1 phenotype supports proinflammatory Th1 responses driven by cytokines such as IL-12 and IL-23, while the alternate M2 phenotype is generally supportive of anti-inflammatory processes driven by IL-10. M2 cells can be further classified into subsets, M2a, M2b, and M2c, based on the type of stimulation and the subsequent expression of surface molecules and cytokines. Recently, IRF5 was found to be a critical transcription factor controlling M1 differentiation while suppressing the M2 phenotype.
 
View macrophage cell markers
 
Mouse and Human Macrophage Reagents

BioLegend provides a large selection of antibody products, ELISAs, and recombinant proteins for mouse and human macrophage studies.

Right: Recombinant Human TGF-β1 inhibits the proliferation of TH-2 cells induced by IL-4
 
Featured Antibodies
Specificity Formats Available
Human CCR7 AF488, AF647, APC, Pacific Blue, PerCP/Cy5.5
Mouse CCR7 AF488, AF647, APC, Biotin, PE, PE/Cy5.5, PerCP/Cy5.5, Purified
Human CD86 AF488, AF647, APC, Biotin, LEAF™, Pacific Blue™, PE, PE/Cy5, PE/Cy7, PerCP/Cy5.5, Purified
Mouse CD86 AF488, AF647, APC, APC/Cy7, Biotin, FITC, LEAF™, Pacific Blue™, PE, PE/Cy5, PE/Cy7, PerCP, PerCP/Cy5.5, Purified
Human CD163 AF647, APC, Biotin, PE, PerCP/Cy5.5, Purified
Human CD206 (MMR) AF488, AF647, APC, APC/Cy7, Biotin, FITC, LEAF™, PE, PE/Cy5, Purified
Mouse CD206 (MMR) AF488, AF647, Biotin, FITC, Purified
Human CD209 AF647, APC, FITC, PE, PerCP/Cy5.5, Purified
Mouse IFNγ AF488, AF647, APC, Biotin, FITC, LEAF™, Pacific Blue™, PE, PE/Cy7, PerCP/Cy5.5, Purified
Human IL-10 AF488, AF647, APC, Biotin, LEAF™, PE, PE/Cy7, Purified
Mouse/Human IRF4 Purified
Human NF-κB p50 AF488, FITC, Purified
Human TLR1 Biotin, PE, Purified
Human TLR4 Biotin, LEAF™, PE, Purified
Mouse TLR4/MD2 Complex Biotin, LEAF™, PE, PE/Cy7, Purified
—>  See all Macrophage cell markers
Featured ELISAs
Description # Pre-coated Plates
LEGEND MAX™ Human FGL2 ELISA Kit 1 or 5
LEGEND MAX™ Free Active TGF-β1 ELISA Kit 1 or 5
LEGEND MAX™ Total TGF-β1 ELISA Kit 1 or 5
LEGEND MAX™ Human IL-6 ELISA Kit 1 or 5
LEGEND MAX™ Mouse IL-6 ELISA Kit 1 or 5
LEGEND MAX™ Rat IL-6 ELISA Kit 1 or 5
Human IL-6 ELISA MAX™ Deluxe 5, 10, or 20
Mouse IL-6 ELISA MAX™ Deluxe 5, 10, or 20
LEGEND MAX™ Human IL-10 ELISA Kit 1 or 5
LEGEND MAX™ Mouse IL-10 ELISA Kit 1 or 5
LEGEND MAX™ Human IL-12 p70 ELISA Kit 1 or 5
LEGEND MAX™ Mouse IL-12 p70 ELISA Kit 1 or 5
LEGEND MAX™ Mouse IL-23 (p19/p40) ELISA Kit 1 or 5
LEGEND MAX™ Human IL-33 ELISA Kit 1 or 5
LEGEND MAX™ Mouse IL-33 ELISA Kit 1 or 5
LEGEND MAX™ Human TNF-α ELISA Kit 1 or 5
LEGEND MAX™ Mouse TNF-α ELISA Kit 1 or 5
—> See all LEGEND MAX™ kits
—> See all ELISA MAX™ sets and kits
Featured Recombinant Proteins
Description Sizes
Recomb. Human TGF-β1 (carrier-free) 10, 25, 100, 500µg
Recomb. human GM-CSF (carrier-free) 10, 25, 100, 500µg
Recomb. mouse GM-CSF (carrier-free) 10, 25, 100, 500µg
Recomb. human IFN-γ (carrier-free) 10, 25, 100, 500µg
Recomb. mouse IFN-γ (carrier-free) 10, 25, 100, 500µg
Recomb. human IL-1β (carrier-free) 10, 25, 100, 500µg
Recomb. mouse IL-1β (carrier-free) 10, 25, 100, 500µg
Recomb. human IL-10 (mammalian expressed, CF) 10, 25, 100µg
Recomb. human IL-10 (carrier-free) 10, 25, 100, 500µg
Recomb. mouse IL-10 (carrier-free) 10, 25, 100, 500µg
Recomb. human IL-12 (p70) (carrier-free) 10, 25, 100, 500µg
Recomb. mouse IL-12 (p70) (carrier-free) 10, 25, 100, 500µg
Recomb. human IL-13 (carrier-free) 10, 25, 10 µg
Recomb. mouse IL-13 (carrier-free) 10, 25, 100, 500µg
Recomb. human IL-23 (carrier-free) 10µg
Recomb.mouse IL-23 (carrier-free) 10µg
—> See all Human Recombinant Proteins
—> See all Mouse Recombinant Proteins
 
Citifluor are mounting media designed to reduce the fading (bleaching) of the fluorescence of fluorochromes.

  • AF1 solution (most frequently used) is an anti-bleaching agent contained in a glycerol PBS solution and is particularly useful for examining tissue sections
  • AF2 solution contains the antifadent in glycerol which enables users to choose their own buffer
  • AF3 is the antifadent in PBS solution and is particularly useful for examining live cells
  • AF87 is a non fluorescent immersion oil containing antifadent
  • CFPVOH is an aqueous solution of poly(vinyl alcohol) for use as a solid mountant
  • AF100 is a solution of antifadents for use with CFPVOH when bleaching of specimens in a solid mountant is a problem

    More about the products
    Pricing
 
 
 
Liquid Blocker Super PapPen
The PapPen is an effective tool for IHC staining procedures. The Super Pap Pen is used for immunohistochemical applications. The hydrophobic properties allow the user to draw barriers on glass slides in any pattern. This will confine the flow of reagents to a defined area. A minimum of valuable anti-serum can be used. Pen markings are resistant to chemicals commonly used, but can be removed by wiping the slide with a tissue or lab wipe. Heat-stable up to 120° C.
  • Save precious antibody or serum solution
  • No need to dry slides: draw markings on wet slides
  • Circles will provide water-resistant containment
  • Not affected by water-soluble mounting media
  • Several sections can be treated on same slide
  • Not affected by temperature up to 120°C
  • Suitable for in situ hybridization
Cat# Product CHF
NAN-011 LIQUID BLOCKER (SUPER PAP PEN) - Mini (Fine point) 55.00
NAN-012 LIQUID BLOCKER (SUPER PAP PEN) - Regular (Broad point) 84.00
 
 
 
  
Cat.#  Supplier Product Qty CHF 
41-903-100 Biological Industries Bovine Serum Albumin Fraction V (cell culture tested) 100gr 156.00
 
 
 

 

   
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