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09.03.2011  
 
Profit from a 10% discount on Merck compounds!
 
Catalog# Product Name Primary Action Qty Price CHF 10% off
3235-10 CDPPB Positive allosteric modulator at mGlu5 10mg 232.00 208.80
3235-50 50mg 984.00 885.60
0281-10 (R)-(+)-HA-966 NMDA partial agonist/antagonist, acts at glycine site 10mg 184.00 165.60
0281-50 50mg 776.00 698.40
0742-10 L-689,560 Very potent NMDA antagonist 10mg 248.00 223.20
0742-50 50mg 1048.00 943.20
0426-10 L-693,403 maleate High affinity σ ligand 10mg 216.00 194.40
0426-50 50mg 863.00 776.70
0781-10 L-694,247 5-HT1D agonist 10mg 255.00 229.50
0781-50 50mg 1135.00 1021.50
0705-10 L-701,252 NMDA antagonist, acts glycine site 10mg 207.00 186.30
0705-50 50mg 863.00 776.70
0868-10 L-732,138 Potent, selective NK1 antagonist 10mg 111.00 99.90
0868-50 50mg 440.00 396.00
3250-10 L-838,417 Subtype-selective GABAA partial agonist 10mg 280.00 252.00
3250-50 50mg 1224.00 1101.60
817-10 MRK 016 α5-selective GABAA inverse agonist 10mg 280.00 252.00
3817-50 50mg 1224.00 1101.60
2921-10 MTEP hydrochloride Potent, selective mGlu5 antagonist 10mg 207.00 186.30
2921-50 50mg 879.00 791.10
3818-10 TCS 1102 Potent, dual orexin receptor antagonist 10mg 216.00 194.40
3818-50 50mg 904.00 813.60
Offer is valid until 30.04.2011
Please fill inquiry form or send email with "SM090311"
Discounts are not summable
   
Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor
3968 | AZD 5438
IC50 values are 16, 6 and 20 nM respectively. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.
 
Related Products: Purvalanol BPHA 767491(R)-DRF053;   View all related products
 
Selective NPY Y2 antagonist
4018 | JNJ 5207787
IC50 = 0.1 μM. Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
 
Related Products: BIIE 0246; S 25585BIBO 3304 trifluoroacetateView all related products
 
Selective inhibitor of MEK1/2
4192 | PD 0325901
Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Orally active.
 
Related Products: PD 198306SL 327U0126View all related products
 
Selective FAAH inhibitor
4175 | PF 3845
Ki = 0.23 μM. Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).
 
Related Products: LY 2183240JNJ 1661010PF 750View all related products
 
Potent and selective NK3 antagonist
3297 | SSR 146977
Ki values are 0.26 and 19.3nM in CHO cells expressing the human NK3 and NK2 receptor respectively. Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50=10nM).
 
Related Products: SB 222200SB 218795SenktideView all related products
 
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